Type II toxin- antitoxin systems in clinical isolates of antibiotic resistant Acinetobacter baumannii

The over use of antibiotics to treat infections in humans and animals made a phenomenon the antibiotic-resistant bacteria. While studies focused find on new but, identification novel antibacterial targets bacteria is very important. By Toxin antitoxin systems this hypothesis could be done, whereas by activation toxin or inactivation an antitoxin, raised kills bacterium. These are attractive target for antimicrobial therapy. However, most important step potency TA system, as target, identify system that prevalent all resistant clinical isolates. So, prevalence different among isolates Acinetobacter baumannii Emam khomeini hospital, Ilam, Iran was evaluated determine which antibiotic A. baumannii. one hundred were identified during one-year period Iran. isolated from hospitalized patients ICU burn patients. All at least antibiotic. Then, subjected evaluation mazEF higBA genes PCR. results showed frequency highBA 72% 39%, respectively. not presented these two challenged. Also, positive gene. more research geographical area should done with functionality genes.